Weihan Li, PhD

Long-term single-molecule tracking of mRNAs using an MS2 sparse labeling approach.

Weihan Li, Louis Degroux, and Robert H. Singer. (In preparation, to be submitted in 2024).  

 

Transcriptome-wide mRNA condensation precedes stress granule formation and excludes stress-induced transcripts.

Hendrik Glauninger, Jared A.M. Bard, Caitlin J. Wong Hickernell, Edo M. Airoldi, Weihan Li, Robert H. Singer, Sneha Paul, Jingyi Fei, Tobin R. Sosnick, Edward W. J. Wallace, and D. Allan Drummond. bioRxiv, 2024. Link

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An improved imaging system that corrects MS2-induced RNA destabilization.

Weihan Li*†, Anna Maekiniemi*†, Hanae Sato, Christof Osman, and Robert H. Singer†. Nature Methods, 2022. (* equal contribution, † correspondence). Link

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Detecting the non-conventional mRNA splicing and translational activation of HAC1 in budding yeast.

Weihan Li†, and Robert H. Singer. Methods in Molecular Biology, 2022. († correspondence). Link

 

Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.

Adrien Le Thomas, Elena Ferri, Scot Marsters, Jonathan M. Harnoss, David A. Lawrence, Iratxe Zuazo-Gaztelu, Zora Modrusan, Sara Chan, Margaret Solon, Cécile Chalouni, Weihan Li, Hartmut Koeppen, Joachim Rudolph, Weiru Wang, Thomas D. Wu, Peter Walter, & Avi Ashkenazi. Nature Communications, 2021. Link

 

A DNA-repair pathway can affect transcriptional noise to promote cell fate transitions.

Ravi V. Desai, Xinyue Chen, Benjamin Martin, Sonali Chaturvedi, Dong Woo Hwang, Weihan Li, Chen Yu, Sheng Ding, Matt Thomson, Robert H. Singer, Robert A. Coleman, Maike M.K. Hansen, Leor S. Weinberger. Science, 2021. Link

 

Protomer alignment modulates specificity of RNA substrate recognition by Ire1.

Weihan Li*, Kelly Crotty*, Diego Garrido Ruiz, Mark Voorhies, Carlos Rivera, Anita Sil, Dyche Mullins, Matthew Jacobson, Jirka Peschek, and Peter Walter. eLife, 2021. (* equal contribution). Link

 

Engineering ER-stress dependent non-conventional mRNA splicing.

Weihan Li†, Voytek Okreglak, Jirka Peschek, Philipp Kimmig, Meghan Zubradt, Jonathan S. Weissman, and Peter Walter†. eLife, 2018. († correspondence). Link

 

Quantitative framework for ordered degradation of APC/C substrates.

Dan Lu, Juliet R. Girard, Weihan Li, Arda Mizrak, and David O. Morgan. BMC Biology, 2015. Link

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Switching between oscillations and homeostasis in competing negative and positive feedback motifs.

Weihan Li, Sandeep Krishna, Simone Pigolotti, Namiko Mitarai, and Mogens H. Jensen. Journal of Theoretical Biology, 2012. Link